Bromoacetonitrile → HCID 86641799, compound

HRID 555774Notes

Reaction equation

HRID 555774 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH2:4][CH2:3]1.Br[CH2:16][C:17]#[N:18]>>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH2:16][C:17]#[N:18])[CH2:11][CH2:10]2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 27369421-((1-Methyl-4-piperidinyl)methyl)piperazine

Product 1

HCID 86641799HCID 86641799, compound

Procedure

The title compound is synthesized by coupling of 1-(1-Methyl-piperidin-4-ylmethyl)-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=237.3.

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-4d0334915479497e8caa09230f17994c
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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