tert-Butyl N-(2-bromoethyl)carbamate → HCID 66987419, compound

HRID 555778Notes

Reaction equation

HRID 555778 reaction equation
Cl.Cl.Cl.[N:4]1([CH2:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)=[O:12])[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[C:20]([O:24][C:25](=[O:30])[NH:26][CH2:27][CH2:28]Br)([CH3:23])([CH3:22])[CH3:21]>>[C:20]([O:24][C:25](=[O:30])[NH:26][CH2:27][CH2:28][N:7]1[CH2:8][CH2:9][N:4]([CH2:10][C:11](=[O:12])[NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:5][CH2:6]1)([CH3:23])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 4103526tert-Butyl N-(2-bromoethyl)carbamateHCID 66987940HCID 66987940, compound

Product 1

HCID 66987419HCID 66987419, compound

Procedure

The title compound is synthesized by coupling of 2-piperazin-1-yl-N-pyridin-2-yl-acetamide trihydrochloride dehydrate (commercially available from ABCR GmbH) and (2-Bromo-ethyl)-carbamic acid tert-butyl ester analogously to the preparation of Intermediate 269.2 as a colorless oil; ES-MS: M+H=364.3: CtRet=4.07.

Workup

  1. customanalogously to the preparation of Intermediate 269.2 as a colorless oil

Sources & evidence

ORD record
ord-cf1b0fbfef08472586ef755b93e01400
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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