1-((Pyrrolidine-1-carbonyl)methyl)piperazine → {2-[4-(2-Oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-carbamic acid tert-butyl ester

HRID 555779Notes

Reaction equation

HRID 555779 reaction equation
[N:1]1([CH2:7][C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:15]([O:19][C:20](=[O:25])[NH:21][CH2:22][CH2:23]Br)([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20](=[O:25])[NH:21][CH2:22][CH2:23][N:4]1[CH2:3][CH2:2][N:1]([CH2:7][C:8](=[O:9])[N:10]2[CH2:11][CH2:12][CH2:13][CH2:14]2)[CH2:6][CH2:5]1)([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 1006141-((Pyrrolidine-1-carbonyl)methyl)piperazineHCID 4103526tert-Butyl N-(2-bromoethyl)carbamate

Product 1

HCID 66987566{2-[4-(2-Oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-carbamic acid tert-butyl ester

Procedure

The title compound is synthesized by coupling of 2-piperazin-1-yl-1-pyrrolidin-1-yl-ethanone (commercially available from CHESS GmbH) and (2-Bromo-ethyl)-carbamic acid tert-butyl ester analogously to the preparation of Intermediate 269.2 as a colorless oil; ES-MS: M+H=341.3: CtRet=4.08.

Workup

  1. customanalogously to the preparation of Intermediate 269.2 as a colorless oil

Sources & evidence

ORD record
ord-7694ab8e0a38467984a3ff4783baefdc
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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