Bromoacetonitrile → (2-Phenyl-imidazol-1-yl)-acetonitrile

HRID 555780Notes

Reaction equation

[C:1]1([C:7]2[NH:8][CH:9]=[CH:10][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:13][C:14]#[N:15]>>[C:1]1([C:7]2[N:11]([CH2:13][C:14]#[N:15])[CH:10]=[CH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 695912-Phenylimidazole

Product 1

HCID 58743635(2-Phenyl-imidazol-1-yl)-acetonitrile

Procedure

The title compound is synthesized by coupling of 2-Phenyl-1H-imidazole and bromoacetonitrile analogously to the preparation of Intermediate 269.4 as a colorless oil; ES-MS: M+H=184.1: CtRef=3.48.

Sources & evidence

ORD record: ord-eca47c72d728434fa4920bf9e75196b0
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08053457B2

Reaction notes

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