4-Toluenesulfonyl chloride → HCID 66987557, compound

Participants

Reaction Steps

50% of NaH in mineral oil (284 mg, 5.9 mmol) is added to a solution of Example 1 (1.65 g, 3.9 mmol) in THF (40 mL) at 0° C. The reaction mixture is allowed to warm to rt and stirred for 15 min. TsCl (902 mg, 4.7 mmol) is added and stirring continued for 1 h. The reaction is quenched by addition of EtOAc and H2O. The organic layer is separated, washed with brine, dried and concentrated. The crude product is purified by tituration with EtOAc/hexanes to give the title compound as a white solid. ES-MS: M+H=573.7: EtRet=5.33 min.

Provenance & Evidence