HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555850Generated: October 31, 2026
Cesium carbonate → 4-(3-(4-(Benzo[D]thiazol-2-ylamino)phenoxy)pyrazin-2-YL)tetrahydro-2H-pyran-4-carbonitrile
https://huagongshe.com/reaction/555850
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-(Benzo[d]thiazol-2-ylamino)phenol | HCID 59326813 | — |
| Reactant | 4-(3-Chloropyrazin-2-YL)tetrahydro-2H-pyran-4-carbonitrile | HCID 59351305 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(3-(4-(Benzo[D]thiazol-2-ylamino)phenoxy)pyrazin-2-YL)tetrahydro-2H-pyran-4-carbonitrile | HCID 59351203 | — |
Reaction Steps
To a solution of 4-(benzo[d]thiazol-2-ylamino)phenol (0.097 g, 0.402 mmol) and 4-(3-chloropyrazin-2-yl)tetrahydro-2H-pyran-4-carbonitrile (0.09 g, 0.402 mmol) in DMSO (1 mL) was added cesium carbonate (0.262 g, 0.805 mmol). The resulting mixture was heated to 60° C. overnight. Purification by Biotage (0-100% EtOAc/hexane) provided product. MS (ESI, pos. ion) m/z: 430.0 (M+1). IC50 (uM) +++++.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08053438B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-7d9daa5ad7ec4d0081791af06b297fca |
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| Source note | uspto-grants-2011_11 |
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