(Diethylamino)sulfur trifluoride → 2-Fluoro-3-(4-fluorotetrahydro-2H-pyran-4-YL)pyrazine

Participants

Reaction Steps

To a solution of 4-(3-fluoropyrazin-2-yl)tetrahydro-2H-pyran-4-ol (0.123 g, 0.621 mmol) in DCM (2 mL) cooled to 0° C. was added dropwise dast (0.164 mL, 1.241 mmol). The resulting mixture was stirred for 2 hr. Reaction was quenched with dropwise addition of saturated NaHCO3 solution and back extracted with DCM to produce product.

Provenance & Evidence