4-(3-(3,6-Dihydro-2H-thiopyran-4-YL)pyrazin-2-yloxy)-N-methoxy-N-methylbenzamide → N-Methoxy-N-methyl-4-(3-(tetrahydro-2H-thiopyran-4-YL)pyrazin-2-yloxy)benzamide

Participants

Reaction Steps

A solution of 4-(3-(3,6-dihydro-2H-thiopyran-4-yl)pyrazin-2-yloxy)-N-methoxy-N-methylbenzamide (0.500 g, 1.399 mmol) in MeOH (10 ml) was hydrogenated at RT in 10% Pd/C (0.200 mg) in 72 h. The solid was filtered off, and the filtrate was concentrated and purified by ISCO (3% MeOH/DCM) to give the title compound. MS [M+1]: 360.1.

Provenance & Evidence