HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 4-methylbenzenesulfonate;methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Clopidogrel | HCID 60606 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-methylbenzenesulfonate;methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate | HCID 86609274 | — |
Reaction Steps
Clopidogrel base was dissolved in methanol to obtain a clear solution. To it was added p-toluenesulfonic acid at 20° C. The reaction mixture was heated to reflux temperature for 2 to 10 hrs. The solvent was evaporated to dryness under reduced pressure to obtain a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053579B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-c21474354bab4cdaa22483d618d0a08f |
| Source note | uspto-grants-2011_11 |