Water → 1-[2-(2-Isopropyl-2H-tetrazol-5-yl)-ethyl]-3-[6-(6-methoxy-pyridin-3-yl)-imidazo[1,2-a]pyridin-2-yl]-urea

Participants

Reaction Conditions

Reaction Steps

Triethylamine (0.54 ml, 3.26 mmol) is added to a stirred mixture of [6-(6-methoxy-pyridin-3-yl)-imidazo[1,2-a]pyridin-2-yl]carbamic acid phenyl ester (Intermediate C) (0.587 g, 1.63 mmol) and 2-(2-isopropyl-2H-tetrazol-5-yl)-ethylamine hydrochloride (Intermediate D1)(0.275 g, 1.96 mmol) in NMP (5 ml). The resulting mixture is stirred at 80° C. for 2 hours and then allowed to cool to room temperature. Water (100 ml) is added and the resulting grey suspension is collected by filtration and dried in a vacuum oven to afford the title compound.

Provenance & Evidence