4-Toluenesulfonyl chloride → HCID 178427410, compound

Participants

Reaction Conditions

Reaction Steps

Tosyl chloride (52.9 g, 277.4 mmol) is added slowly to a stirred solution of 2-amino-5-bromopyridine (40.0 g, 231 mmol) in dry pyridine (240 ml) at 0° C. The reaction is heated at 90° C. for 16 hours. The solvent is removed in vacuo and water (500 ml) is added and the mixture is stirred for 30 minutes at room temperature. The title compound is collected by filtration and dried in a vacuum oven at 50° C.

Provenance & Evidence