HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 2-(Chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(3-Methoxypropoxy)-3-methyl-2-pyridinemethanol | HCID 10465749 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(Chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine | HCID 11031667 | — |
Reaction Steps
To a mixed solution of 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine (12.02 g (56.9 mmol)) and toluene (96.0 ml) was added dropwise thionyl chloride (8.11 g (68.2 mmol)), so that the internal temperature did not exceed 25° C., which was stirred for about 90 minutes at room temperature. Ethanol (24.0 ml) was added to this mixed solution to obtain a 2-chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053580B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-12161e8f4c2d45a4a2d1aa4c111bb6ae |
| Source note | uspto-grants-2011_11 |