反应详情

A procedure similar to that in Example 4 was used, 5-benzyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine prepared in Example 1 and p-chlorobenzoyl chloride were used as starting materials, the resulting crude product was recrystallized with acetone to obtain a product as a white solid in a yield of 69.4%, mp: 182-183 └. 1H-NMR (CDCl3, 400 MHz) δ: 3.78 (3H, s, OCH3), 4.21 (2H, s, CH2), 6.75 (2H, d, J=7.56 Hz, ArH), 7.22˜7.35 (9H, m, ArH), 7.60 (2H, d, J=7.56 Hz, ArH), 11.70 (1H, br, CONH); EI-MS m/e (%): 434.2 (M+, 100), 123.0 (83); HREI-MS Calcd. for C24H19ClN2O2S: 434.0856. found: 434.0859. Anal. Calcd. for C24H19ClN2O2S: C, 66.28; H, 4.40; N, 6.44. found: C, 65.91; H, 4.22; N, 6.50.

1. customthe resulting crude product was recrystallized with acetone