反应详情

A procedure similar to step 2 of Example 1 was used. 3-(4-nitro-phenyl)-propionyl chloride prepared in the step 2 of Example 6 and fluorobenzene were used as starting materials, and anhydrous AlCl3 was used as catalyst. The obtained product was a white solid in a yield of 61.2%, mp: 122-124 └. 1H-NMR (CDCl3, 400 MHz) δ: 3.19 (2H, t, J=7.28 Hz), 3.32 (2H, t, J=7.28 Hz), 7.14 (2H, t, 3JFH=3JHH=8.40 Hz, ArH), 7.42 (2H, d, J=8.40 Hz, ArH), 7.99 (2H, dd, 3JHH=7.84, 4JFH=5.60 Hz, ArH), 8.16 (2H, d, J=8.40 Hz, ArH); EI-MS m/e (%): 273.1 (M+, 55), 123.0 (100).