反应详情

A procedure similar to that in Example 7 was used. N-[5-benzyl-4-(4-methoxy-phenyl)-thiazol-2-yl]-2,4-dimethoxy-benzamide prepared in Example 35 and boron tribromide were used as starting materials. The obtained crude product was recrystallized with acetone to give a product as a white solid in a yield of 67.1%, mp: 217-219 └. 1H-NMR (400 Hz, Acetone-d6) δ: 4.40 (2H, s, CH2), 6.53 (1H, d, J=2.24 Hz, ArH), 6.58 (1H, dd, J=8.96 Hz, 2.24 Hz, ArH), 7.04 (2H, d, J=8.68 Hz, ArH), 7.32˜7.40 (5H, m, ArH), 7.65 (2H, d, J=8.68 Hz, ArH), 8.29 (1H, d, J=8.72 Hz, ArH); EI-MS m/e (%): 418.2 (M+, 33), 282.1 (100); HREI-MS Calcd. for C23H18N2O4S: 418.0987. found: 418.0970.

1. customThe obtained crude product
2. customwas recrystallized with acetone