3,5-Dimethoxybenzoyl chloride → HCID 57991577, compound

Participants

Reaction Steps

A procedure similar to that in Example 4 was used. 5-benzyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine prepared in Example 1 and 3,5-dimethoxy-benzoyl chloride prepared in the step 1 were used as starting materials, allowed to react at room temperature overnight, followed by post-treatment to obtain a crude product, which was purified by a silica gel column chromatography eluted with a gradient of dichloromethane and ethyl acetate (100:0-10:1) to obtain a product as a white solid in a yield of 65.7%, mp: 152-153 └. 1H-NMR (CDCl3, 400 MHz) δ: 3.78 (6H, s, 2×OCH3), 3.80 (3H, s, OCH3), 4.22 (2H, s, CH2), 6.55 (1H, t, J=2.12 Hz, ArH), 6.83 (2H, d, J=8.68 Hz, ArH), 6.90 (2H, t, J=2.12 Hz, ArH), 7.25˜7.33 (5H, m, ArH), 7.39 (2H, d, J=8.68 Hz, ArH), 10.75 (1H, br, CONH); EI-MS m/e (%): 460.2 (M+, 100), 165.0 (84); HREI-MS Calcd. for C26H24N2O4S: 460.1457. found: 460.1464.

Provenance & Evidence