Boron tribromide → HCID 57991603, compound

Participants

Reaction Steps

A procedure similar to that in Example 7 was used. N-[5-benzyl-4-(4-methoxy-phenyl)-thiazol-2-yl]-3,5-dimethoxy-benzamide prepared in Example 43 and boron tribromide were used as starting materials. The obtained crude product was recrystallized with acetone to give a product as a white solid in a yield of 48.2%, mp: 262-263 └. 1H-NMR (DMSO-d6, 400 MHz) δ: 4.21 (2H, s, CH2), 6.44 (1H, t, J=2.12 Hz, ArH), 6.83 (2H, d, J=8.40 Hz, ArH), 6.88 (2H, d, J=2.24 Hz, ArH), 7.22˜7.26 (3H, m, ArH), 7.32˜7.35 (2H, m, ArH), 7.46 (2H, d, J=8.68 Hz, ArH), 9.52 (2H, br, OH), 12.39 (1H, br, CONH); EI-MS m/e (%): 418.1 (M+, 82), 282.1 (66), 137.0 (100); HREI-MS Calcd. for C23H18N2O4S: 418.0987. found: 418.0981.

Provenance & Evidence