Boron tribromide → HCID 57991579, compound

Participants

Reaction Steps

A procedure similar to that in Example 7 was used. 3,4,5-trimethoxy-N-[4-(4-methoxy-phenyl)-5-methyl-thiazol-2-yl]-benzamide prepared in Example 53 and boron tribromide were used as starting materials. The obtained crude product was recrystallized with acetone to give a product as a white solid in a yield of 60.5%, mp: 262-263 └. 1H-NMR (DMSO-d6, 400 MHz) δ: 2.36 (3H, s, CH3), 6.76 (2H, d, J=8.80 Hz, ArH), 7.02 (2H, s, ArH), 7.41 (2H, d, J=8.80 Hz, ArH), 9.10 (2H, br, OH), 9.50 (1H, br, OH), 12.06 (1H, br, CONH); EI-MS m/e (%): 358.1 (M+, 25), 206.2 (100), 153.1 (20); HREI-MS Calcd. for C17H14N2O5S: 358.0623. found: 358.0621.

Provenance & Evidence