Hydrochloric Acid → HCID 23655017, compound

Participants

Reaction Steps

0.4 g (1.09 mmol) 1-[5-benzyl-4-(4-methoxy-phenyl)-thiazol-2-yl]-piperazine prepared in Example 71 was dissolved in 20 ml ethyl acetate, cooled in ice-bath, added a 2 mol/L solution of hydrochloride in ethyl acetate under stirring, and a yellow solid was produced, which was filtered in vacuo, and washed with ethyl acetate to give 3.4 g product as a yellow solid in a yield of 77.3%, mp: 111-112 └. 1H-NMR (DMSO-d6, 400 MHz) δ: 3.19 (4H, m, 2×CH2), 3.62 (4H, m, 2×CH2), 3.79 (3H, s, OCH3), 4.12 (2H, s, CH2), 5.58 (2H, br, exchangeable, 2×NH), 6.98 (2H, d, J=8.80 Hz, ArH), 7.18˜7.32 (5H, m, ArH), 7.52 (2H, d, J=8.80 Hz, ArH), 9.34 (2H, br, exchangeable, 2×NH); EI-MS m/e (%): 365.0 (M−3, 81), 323.0 (26), 309.0 (100), 295.9 (51); HREI-MS Calcd. for C21H23N3OS: 365.1562. found: 365.1564.

Provenance & Evidence