Boron tribromide → HCID 57991593, compound

Participants

Reaction Steps

A procedure similar to that in Example 74 was used. 1-[5-benzyl-4-(4-methoxy-phenyl)-thiazol-2-yl]-piperazine prepared in Example 71 and a solution of boron tribromide in dichloromethane were used as starting materials. The obtained crude product was recrystallized with acetone to give a product as a white solid in a yield of 49.2%, mp: 222-223 └. 1H-NMR (DMSO-d6, 400 MHz) δ: 2.71 (2H, s, CH2), 3.20 (2H, m, CH2), 3.40 (1H, br, NH), 4.01 (2H, s, CH2), 6.70 (2H, d, J=8.00 Hz, ArH), 7.05˜7.25 (2H, m, ArH), 7.31 (2H, d, J=8.00 Hz, ArH), 9.48 (1H, s, OH); EI-MS m/e (%): 351.1 (M+, 77), 309.0 (29), 295.0 (100), 282.0 (42); HREI-MS Calcd. for C20H21N3OS: 351.1405. found: 351.1406.

Provenance & Evidence