Formaldehyde → HCID 24857671, compound

Participants

Reaction Steps

The respective methylamine 7 (e.g., 28.4 mg, 0.0927 mmol) was dissolved in 96% formic acid (0.5 mL) and 37% aqueous formaldehyde (0.5 mL) and heated at 100° C. for two hours. After cooling, the solution was basicified (aq KOH) and extracted with MTBE. The organic phase was dried with sodium sulfate, filtered, and evaporated to give the dimethylamine (e.g., 27.1 mg, 93%) as a clear oil.

Provenance & Evidence