Water → 3-Bromomethyl-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene

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Reaction Steps

To a solution of compound 11 (1.25 g, 4.07 mmol) and CBr4 (2.33 G, 7.04 mmol) in CH2Cl2 (15 ml) was added Ph3P (1.82 g, 6.92 mmol) in CH2Cl2 (15 ml) at 0° C. The reaction was allowed to warm to room temperature overnight, was then poured into water ((40 ml), extracted with CH2Cl2 (75 ml), dried over Na2SO4, and the solvent was evaporated. The residue was purified by chromatography, CombiFlash silica gel column, EtOAC hexanes, EtOAc from 0% to 15%, to give compound 12 as a clear oil (mixture of cis and trans diastereomers, 1.50 g, 99%). 1H NMR. (CDCl3) δ 1.52-1.62 (m) and 1.97-2.15 (m, total 2H), 2.25-2.30 (m, 1H), 2.64-2.77 (m, 1H), 3.02-3.12 (m, 1H), 3.34-3.47 (m, 2H), 4.08 (dd, J=12 Hz, 5.2 Hz) and 4.26 (t, J=3.6 Hz, total 1H), 6.72-7.39 (m, 7H). 13C NMR (CDCl3) δ 31.8, 34.6, 35.6, 36.8, 37.2, 39.2, 39.3, 39.4, 43.3, 46.4, 126.5, 126.8, 126.9, 127.2, 128.3, 128.4, 128.6, 129.0, 129.4, 129.5, 129.7, 130.2, 130.5, 130.7, 130.9, 132.5, 132.8, 136.1, 136.3, 138.3, 147.0, 147.5.

Provenance & Evidence