Sodium cyanoborohydride → HCID 66809062, compound

Participants

Reaction Steps

To a solution of the tetralone 30a in THF in methanol was added methylamine hydrochloride. After dissolution (10 min), sodium cyanoborohydride was added in a single portion. The resultant mixture was stirred at 50° C. for three hours. After cooling, the mixture was diluted with sodium bicarbonate solution and extracted with MTBE. The organic layer was evaporated to give the crude amine 32a (160 mg) as a mixture of four configurational isomers.

Provenance & Evidence