反应详情

To a solution of 60 (30 mg, 0.089 mmol) in acetic acid (3 mL) was added palladium on charcoal (30 mg, 5%). The mixture was then stirred under hydrogen (1 atm) for 1 h. The catalyst was filtrated away through a pad of Celite. The filtrate was concentrated. The resultant residue was purified by chiral OJ column (ethanol/methanol/hexane/DEA=3:2:95:0.1) to give 59 (12.5 mg, 44%). 1H NMR (400 MHz, CDCl3) δ 8.10 (d, J=8.0 Hz, 1 H), 7.44-7.38 (m, 2 H), 7.38-7.24 (m, 2 H), 6.81 (d, J=7.6 Hz, 1 H), 7.03 (dd, J=1.6, 8.0 Hz, 1 H), 4.28 (dd, J=4.4, 12.4 Hz, 1 H), 2.19 (dd, J=13.6, 12.4 Hz, 1 H), 2.06 (dd, J=13.6, 4.4 Hz, 1 H), 1.58 (s, 1 H), 1.27 (s, 6 H); 13C NMR (100 MHz, CDCl3) δ 145.39, 144.92, 133.53, 133.01, 133.68, 131.19, 131.09, 131.01, 129.24, 128.51, 128.31

1. filtrationThe catalyst was filtrated away through a pad of Celite
2. concentrationThe filtrate was concentrated
3. customThe resultant residue was purified by chiral OJ column (ethanol/methanol/hexane/DEA=3:2:95:0.1)