Hydrochloric Acid → HCID 178419169, compound

Participants

Reaction Steps

Under an argon atmosphere, a solution of cerium chloride (7.89 g, 3.0 equivalents) in THF (20 mL) was stirred at room temperature (25° C.) for 30 min. Sodium borohydride (1.25 g, 3.1 equivalents) was added, and the mixture was stirred at room temperature for 1 hr. Then bis(4-methylphenyl)phosphine oxide (2.5 g, 0.011 moL) synthesized in Reference Example 8 and lithium aluminum hydride (0.494 g, 1.2 equivalents) were successively added at 5° C., and the mixture was stirred at room temperature for 17 hrs. Water (10 mL) was added at 3° C. and then toluene (20 mL) and 6M-HCl (20 mL) were added. The mixture was stirred at room temperature for 30 min. The reaction mixture was partitioned, and the aqueous layer was extracted with toluene (30 mL). The combined organic layer was washed successively with 5% aqueous NaHCO3 solution (20 mL) and 5% aqueous NaCl solution (20 mL). Then the organic layer was dried over anhydrous magnesium sulfate, filtered by gravity, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (alumina 25 g, n-hexane/ethyl acetate=10/1). The residue was recrystallized from heptane to give the title compound (1.28 g, white crystals). yield 51.0%. melting point: 78.6° C.

Provenance & Evidence