Ammonia → HCID 11455930, compound

Participants

Reaction Steps

The reaction of Step (1) is as shown below. Specifically, 150 mg of caprazamycin B were dissolved in 1.5 mL of N,N-dimethylformamide. To this solution, 1.5 mL of 28% aqueous ammonia were added and the resulting mixture was stirred at room temperature for 4 days for hydrolysis. The insoluble material developed in the reaction mixture was removed by filtration and the filtrate was concentrated. The resulting residue was washed with acetone and dried to afford 74.7 mg of caprazol as a colorless solid (99% yield).

Provenance & Evidence