HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 6-Methoxy-benzo[d]isothiazole-3-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Propylphosphoric anhydride | HCID 16167369 | — |
| Reactant | AP-24592 | HCID 46838908 | — |
| Reactant | 6-Methoxybenzo[d]isothiazole-3-carboxylic acid | HCID 66636805 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Methoxy-benzo[d]isothiazole-3-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide | HCID 66992887 | — |
Reaction Steps
Prepared analogousely to step 6.1 from 2.0 g (9.57 mMol) 6-methoxy-benzo[d]isothiazole-3-carboxylic acid, 3.9 g (14.3 mMol) 4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-aniline, 13.3 ml (95.7 mMol) Et3N and 11.17 ml (50% in DMF; 19.1 mMol) propylphosphonic anhydride in 100 ml of dry DMF: m.p.: 156° C.; MS: [M+1]+=465.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058276B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-abd1e87f040e41bcbe395dc1d49e6f16 |
| Source note | uspto-grants-2011_11 |