HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Phosphate, Tribasic → 6-(2-Amino-6-chloro-pyrimidin-4-yloxy)-benzo[d]isothiazole-3-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| Reactant | HCID 136346629 | HCID 136346629 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 6-(2-Amino-6-chloro-pyrimidin-4-yloxy)-benzo[d]isothiazole-3-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide | HCID 86626626 | — |
Reaction Steps
Prepared as described in step 6.3 from 401 mg (2.45 mMol) 2-amino-4,6-dichloropyrimidine, 785 mg (1.74 mMol) 6-hydroxy-benzo[d]isothiazole-3-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-amide and 1.5 g (7.1 mMol) K3PO4 in 45 ml NMP: MS: [M+1]+=578/580; HPLC: tRet=14.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058276B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-45d407ae9d2545ecaaed3179b81d2890 |
| Source note | uspto-grants-2011_11 |