Ethyl Acetate → HCID 86626630, compound

Participants

Reaction Conditions

Reaction Steps

58.9 mg Product from Step 15.6 (0.31 mMol) are dissolved in 8 ml NMP and treated with 268 mg (1.2 mMol) K3PO4 and 75 mg (0.46 mMol) 2-amino-4,6-dichloropyrimidine at rt. The reaction mixture is warmed to 70° C. and stirred for 20 h at rt. It is worked up by addition of EtOAc and washed with H2O. The organic layer is dried and concentrated to give the crude product which is purified by recrystallization from EtOAc to give the title compound as a white powder: MS: [M+1]+=320; 1H MNR (DMSO-d6): δ ppm 9.18 (s, 1H), 8.43 (s, 1H), 8.09 (d, 1H), 7.60 (d, 1H), 7.21 (bs, 2H, NH2), 6.42 (s, 1H), 3.82 (s, 3H).

Provenance & Evidence