Potassium Phosphate, Tribasic → HCID 57556447, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 984 mg (4.05 mMol) hexanoic acid 6-chloro-pyrimidin-4-ylmethyl ester, 751 mg (3.38 mMol) 6-hydroxy-benzo[b]thiophene-3-carboxylic acid ethyl ester (Step 12.3) and 1.43 g (6.76 mMol) K3PO4 in 20 ml NMP is stirred for 1.5 h at 60° C. The reaction mixture is dissolved in water and EtOAc, the aq. phase separated off and extracted twice with EtOAc. The organic layers are washed with water and brine, dried (Na2SO4) and concentrated. Chromatography (SiO2; hexane/EtOAc 4:1→1:1) gives the title compound: MS: [M+1]+=429; TLC(hexane/EtOAc 4:1): Rf=0.14.

Provenance & Evidence