反应详情

0.20 g (0.46 mmol) 4-ethoxy-9-methyl-2-piperazin-1-yl-7-(4-vinylphenyl)-thieno[2,3-d:4,5-d′]dipyrimidine and 0.16 g (1.39 mmol) N-methylmorpholine-N-oxide-monohydrate were dissolved in 50 ml acetone. Then, 0.3 ml (4% aqueous) OSO4 solution was added and stirring was carried out at room temperature for 24 h. Thereafter, 100 ml 1 M NaCO3 solution were added and extraction with dichloromethane was carried out. Following flash chromatographic purification (chloroform/methanol, 8.5:1.5) 100 mg (46%) of the title compound is obtained. ESI-MS [m/z]: 466, melting point: >300° C.

1. extractionextraction with dichloromethane
2. customchromatographic purification (chloroform/methanol, 8.5:1.5) 100 mg (46%) of the title compound
3. customis obtained