HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 556403Generated: October 25, 2026
Ethyl Acetate → 7-(4-n-Butoxy-phenyl)-4-ethoxy-9-methyl-2-piperazin-1-yl-thieno[2,3-d:4,5-d']dipyrimidine
https://huagongshe.com/reaction/556403
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Butoxyphenol | HCID 31233 | — |
| Reactant | 7-(4-Bromophenyl)-4-ethoxy-9-methyl-2-piperazin-1-yl-thieno[2,3-d:4,5-d']dipyrimidine | HCID 59755063 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 7-(4-n-Butoxy-phenyl)-4-ethoxy-9-methyl-2-piperazin-1-yl-thieno[2,3-d:4,5-d']dipyrimidine | HCID 66991918 | — |
Reaction Steps
100 mg (0.21 mmol) 7-(4-bromophenyl)-4-ethoxy-9-methyl-2-piperazin-1-yl-thieno[2,3-d:4,5-d′]dipyrimidine, 51 mg (0.31 mmol) 4-n-butoxyphenol, 134 mg (0.41 mmol) Cs2CO3, 1 μl (5 mole %) ethyl acetate and 1.5 mg (5 mole %) CuBr were suspended in 5 ml absolute toluene and heated in a microwave oven at 180° C. for 17 h. Thereafter, the solvent was removed and the residue was purified by means of flash chromatography. 4 mg (3%) of the title substance is obtained. ESI-MS [m/z]: 571
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08058285B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-884943c3187e4723b65f9f125527d23f |
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| Source note | uspto-grants-2011_11 |
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