Ethanol → HCID 59755067, compound

HRID 556407Notes

Reaction equation

HRID 556407 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][C:9]3[N:11]=[C:12]([C:16]4[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH3:25])[CH:17]=4)[CH:13]=[C:14]([CH3:15])[C:8]=3[C:6]=2[N:7]=1.C[O-].[Na+].[CH2:30]([OH:32])[CH3:31]>>[Cl:1][C:2]1[N:3]=[C:4]([O:32][CH2:30][CH3:31])[C:5]2[S:10][C:9]3[N:11]=[C:12]([C:16]4[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH3:25])[CH:17]=4)[CH:13]=[C:14]([CH3:15])[C:8]=3[C:6]=2[N:7]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 10942334Sodium MethoxideHCID 23109286HCID 23109286, compound

Product 1

HCID 59755067HCID 59755067, compoundYield 90%

Procedure

1.5 g (3.7 mmol) 2,4-dichloro-7-(3,4-dimethoxyphenyl)-9-methyl-pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidine and 0.7 g (11.1 mmol) sodium methylate are added by stirring to 50 ml absolute ethanol at room temperature for 24 h. Then, the precipitate is sucked off, washed with about 40 ml water, suck dried and dried in vacuo at 50° C. 1.38 g (90%) 2-chloro-4-ethoxy-7-(3,4-dimethoxyphenyl)-9-methyl-pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidine is obtained.

Workup

  1. washwashed with about 40 ml water, suck
  2. customdried
  3. customdried in vacuo at 50° C

Sources & evidence

ORD record
ord-ab24e6c1aec444529e3d371c1e3b3914
Source dataset
uspto-grants-2011_11
Patent number
US08058285B2

Reaction notes

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