HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylvinyltin → HCID 17877573, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Reactant | 2-Bromo-1H-imidazo[4,5-b]pyridine | HCID 18521647 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 17877573 | HCID 17877573 | — |
Reaction Steps
A solution of bromoimidazo[4,5-b]pyridine (1 eq.), tributyl(vinyl)tin (1.5-3 eq.), and tetrakis(triphenylphosphine)palladium(0) (0.1 eq.) in toluene (deoxygenated with N2, 20 ml/mmol ml) is stirred under reflux for 4 h. Concentration in vacuo and chromatographic purification (EtOAc/hexane gradient) yields the corresponding vinylimidazo[4,5-b]pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058289B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-6c2755fd12534cb6bf5940d3664a6fc6 |
| Source note | uspto-grants-2011_11 |