L-Phenylalanine → HCID 66991917, compound

Participants

Reaction Conditions

Reaction Steps

To an aqueous solution of NaOH (1N, 10 mL) at 0° C. was added L-2-amino-3-phenyl-propionic acid (1.47 g, 8.92 mmol), followed by the addition of solution of 3,6-dichloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one (3 g, 8.1 mmol) in 1,4-dioxane (3 mL). After the reaction mixture was stirred at 0° C. for 4 h, the solution was concentrated and extracted with diethyl ether. The organic layer was dried over Na2SO4, filtered and concentrated.

Provenance & Evidence