2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 59703630, compound

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Reaction Steps

The solution of rac-6′-Chloro-3′-(3-chloro-benzyl)-6-methoxy-2′-oxo-2,3,2′,3′-tetrahydro-1′H-[1,3′]biindolyl-2-carboxylic acid ethyl ester (1.0 g, 1.9 mmol) and DDQ (0.73 g, 3.2 mmol) in toluene (50 mL) was heated to 90° C. for 4 h. Then the mixture was cooled to room temperature and washed with NaOH solution (10%) and water. The organic layer was dried with Na2SO4, concentrated in vacuo to give 0.9 g rac-6,6′-Dichloro-3′-(3-chloro-benzyl)-2′-oxo-2′,3′-dihydro-1′H-[1,3′]biindolyl-2-carboxylic acid ethyl ester as yellow solid. MS: [M+H]+=513

Provenance & Evidence