Cyclobutanecarboxylic acid → HCID 57507257, compound

Participants

Reaction Steps

The mixture of rac-3-[(2-Amino-ethyl)-isopropyl-amino]-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one (60 mg, 0.15 mmol), cyclobutanecarboxylic acid (18.4 mg, 0.18 mmol), EDCl (37 mg, 0.19 mmol), HOBt (30 mg, 0.19 mmol) and DIPEA (40 uL, 0.225) in DCM (2 mL) was stirred at root temperature for 2 hr. The mixture was purified by flash column chromatography to give 60 mg rac-Cyclobutanecarboxylic acid (2-{[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-isopropyl-amino}-ethyl)-amide. MS: [M+H]+=474

Provenance & Evidence