2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 59703629, compound

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Reaction Steps

At room temperature, 6′-Chloro-3′-(3-chloro-benzyl)-2-(morpholine-4-carbonyl)-2,3,1′,3′-tetrahydro-[1,3′]biindolyl-2′-one (60 mg, 0.115 mmol) and DDQ (47 mg, 0.207 mmol) were dissolved in 5 ml toluene. After stirred overnight, the solution was concentrated and then the residue was dissolved in EtOAc. The organic layer was washed with 10% NaOH aqueous solution and dried, concentrated to obtain crude product. The crude product was purified by chromatography to obtain 20 mg yellow solid rac-6′-Chloro-3′-(3-chloro-benzyl)-2-(morpholine-4-carbonyl)-1′,3′-dihydro-[1,3′]biindolyl-2′-one. MS: 520 (M+H)+.

Provenance & Evidence