Sodium Methoxide → HCID 59639594, compound

HRID 556580Notes

Reaction equation

HRID 556580 reaction equation
CO[C:3](=[O:29])/[CH:4]=[CH:5]/[C:6]1[C:7]([NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[Cl:28])=[N:8][C:9](SC)=[N:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[F:18].[CH3:30][O-:31].[Na+]>>[Cl:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[N:21]1[C:7]2[N:8]=[C:9]([O:31][CH3:30])[N:10]=[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[F:18])[C:6]=2[CH:5]=[CH:4][C:3]1=[O:29]

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 66893234HCID 66893234, compound

Product 1

HCID 59639594HCID 59639594, compound

Procedure

Prepared as described above in Example 98 starting from (E)-3-[4-(2-chloro-phenylamino)-6-(2-fluoro-phenyl)-2-methylsulfanyl-pyrimidin-5-yl]-acrylic acid methyl ester and sodium methoxide to afford the title compound 8-(2-chloro-phenyl)-4-(2-fluoro-phenyl)-2-methoxy-8H-pyrido[2,3-d]pyrimidin-7-one. 1H-NMR (CDCl3) δ 3.70 (s, 3H), 6.59 (d, 1H, J=9.7 Hz), 7.01-7.20 (m, 3H), 7.40 (m, 2H), 7.56 (m, 4H); LC MS (m/e)=382 (MH+). Rt=2.24 min

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5db0da54d0a1469da86402306bacd7d3
Source dataset
uspto-grants-2011_11
Patent number
US08058282B2

Reaction notes

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