HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-methyl-1-propanol → HCID 59639547, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Reactant | 8-(2,6-difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one | HCID 59639554 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59639547 | HCID 59639547 | — |
Reaction Steps
The product of Example 48 (200 mg, 0.45 mmol) and 95% 2-amino-2-methyl-1-propanol (94 mg, 1 mmol) were dissolved in THF (10 ml) and stirred under Ar at 50° for 3 days. The solvents were removed in vacuo, and the residue was partitioned between EtOAc and H2O. The organic phase was washed with H2O, satd aq NaCl, dried over anhyd Na2SO4, filtered and evaporated to give the crude product. Flash chromatography eluted with 0-15% EtOAc/CH2Cl2 gave the title compound as a off-white amorphous solid. mp 99-105° C., LC MS m/z=455 (MH+) Retention time=2.19 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058282B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-15f9f7931f5e41f88ca5ed8b449fdaeb |
| Source note | uspto-grants-2011_11 |