3-Fluorophenyl isocyanate → 1-[2-[8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]ethyl]-3-[3-fluorophenyl]urea

Participants

Role	Name	HCID	Charge
Reactant	3-Fluorophenyl isocyanate	HCID 123064	—
Reactant	2-[(2-Aminoethyl)amino]-8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one	HCID 59639577	—
Product	1-[2-[8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]ethyl]-3-[3-fluorophenyl]urea	HCID 59639636	67.6%

Reaction Steps

The title compound from Example 157 (42.3 mg, 0.0001 mol) was treated with 3-fluorophenylisocyanate (12 mg, 0.0001 mol) in the same manner as described in Example 158. Purification afforded 38 mg (67.6%) of the title compound as a light yellow solid (m.p. 131°-144°) LC MS (m/e)=563 (MH+). Rt=2.22 min.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08058282B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-b734e40dcfa84d6d9bedee24448a3745
Source note	uspto-grants-2011_11