反应详情

A solution of 2-methoxy-5-(trifluoromethyl)benzoic acid (0.68 g, 3.1 mmol) in thionyl chloride (10 mL) was warmed to reflux and was allowed to stir for 2 h. The mixture was cooled to ambient temperature, concentrated under reduced pressure and diluted with 10 mL of toluene. This material was again concentrated under reduced pressure and was again diluted with 10 mL of toluene. This concentration and dilution was repeated for an additional time and the crude acid chloride was carried on to the next step.

1. temperatureto reflux
2. concentrationconcentrated under reduced pressure
3. additiondiluted with 10 mL of toluene
4. concentrationThis material was again concentrated under reduced pressure
5. additionwas again diluted with 10 mL of toluene
6. concentrationThis concentration and dilution