2-Amino-5-methylthiazole → HCID 66660839, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-amino-5-methylthiazole (0.58 g, 5.0 mmol) and 3-(Boc-amino)propyl bromide (1.2 g, 5.0 mmol) was warmed to 85° C. and was allowed to stir for 4 h. The mixture was cooled to ambient temperature and was purified via column chromatography (SiO2, 9:1:0.1 CH2Cl2:methanol:ammonium hydroxide) to give the title compound (0.96 g, 3.5 mmol, 70% yield). MS (DCI/NH3) m/z 272 (M+H)+.

Provenance & Evidence