HRID556724

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7371

Benzenesulfonic acid

C6H6O3S

结构：CCN(CC)CCN(CCNCCc1ccc(O)c2[nH]c(=O)sc12)C(=O)CCOCCc1cccc2ccccc12

HCID16035068

N-[2-(Diethylamino)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-3-[2-(1-naphthyl)ethoxy]propanamide

C32H42N4O4S

PRODUCTS

生成物

结构：CCN(CC)CCN(CCNCCc1ccc(O)c2[nH]c(=O)sc12)C(=O)CCOCCc1cccc2ccccc12.O=S(=O)(O)c1ccccc1

HCID25030848

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Benzenesulfonic acid (158.51 mg) was added to a solution of N-[2-(diethylamino)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-3-[2-(1-naphthyl)ethoxy]propanamide (0.58 g) in methanol (5.8 mL) producing an clear solution. The mixture was stirred at room temperature for 1 h. The title compound was obtained as an amorphous solid after evaporation to dryness.

WORKUP

后处理

customproducing an clear solution

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bc4195bce3b34e6c9fabd16a6e0d38f9
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08058294B2
来源说明: uspto-grants-2011_11

反应 SMILES

[C:1]1([S:7]([OH:10])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:11]([N:13]([CH2:50][CH3:51])[CH2:14][CH2:15][N:16]([CH2:34][CH2:35][NH:36][CH2:37][CH2:38][C:39]1[C:47]2[S:46][C:45](=[O:48])[NH:44][C:43]=2[C:42]([OH:49])=[CH:41][CH:40]=1)[C:17](=[O:33])[CH2:18][CH2:19][O:20][CH2:21][CH2:22][C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][CH:24]=1)[CH3:12]>CO>[S:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([OH:10])(=[O:9])=[O:8].[CH2:50]([N:13]([CH2:11][CH3:12])[CH2:14][CH2:15][N:16]([CH2:34][CH2:35][NH:36][CH2:37][CH2:38][C:39]1[C:47]2[S:46][C:45](=[O:48])[NH:44][C:43]=2[C:42]([OH:49])=[CH:41][CH:40]=1)[C:17](=[O:33])[CH2:18][CH2:19][O:20][CH2:21][CH2:22][C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][CH:24]=1)[CH3:51]