Water → HCID 66991975, compound

Participants

Reaction Steps

2.98 g (13.8 mmol) 2a, 1.2 eqv. of tributyl-[1,3]dioxolan-2-ylmethyl-λ5-phosphane and 1.5 eqv. KOtBu in DMSO was stirred at 60° C. for 24 hours. The reaction was monitored by TLC (EtOAc:petroleum ether 1:2). After cooling, the reaction mixture was poured into water and extracted with ether and the solvent was evaporated. The semi-solid residue was diluted with ether and filtrated to remove residual Bu3PO and the product was purified by column chromatography (EtOAc: petroleum ether 1:2) to yield 2.6 g (66%) of 3a.

Provenance & Evidence