HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86652390, compound → HCID 178476709, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86652390 | HCID 86652390 | — |
| Reactant | HCID 178513185 | HCID 178513185 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178476709 | HCID 178476709 | 55% |
Reaction Steps
2 g (8.3 mmol) 4a and 1.1 eqv. of aminoguanidine bicarbonate was mixed in THF and refluxed for 30 min. The solvent was evaporated and the residue was diluted with acetonitrile and the product crystallised. Purification by recrystallisation from acetonitrile yielded 1.35 g (55%) of the final product 5a (m.p. 192-194° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058306B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-ad9161cddaa149189ecdf649df4257e4 |
| Source note | uspto-grants-2011_11 |