HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2,5-dimethoxy-2,5-dihydrofuran-3-carboxylate → Ethyl 2,5-dimethoxy-tetrahydrofuran-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2,5-dimethoxy-2,5-dihydrofuran-3-carboxylate | HCID 59613511 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl 2,5-dimethoxy-tetrahydrofuran-3-carboxylate | HCID 19106911 | 91% |
Reaction Steps
Ethyl 2,5-dimethoxy-2,5-dihydrofuran-3-carboxylate (615 mg, 3.044 mmol) was dissolved in methanol (10 mL) and treated with hydrogen (10 bar) over Raney nickel at 40° C. for 2 h. The reaction mixture was evaporated to dryness to give ethyl 2,5-dimethoxy-tetrahydrofuran-3-carboxylate (564 mg, 91%) which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058045B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-5ff41a681fbd41ba86592f22b3d6ebd2 |
| Source note | uspto-grants-2011_11 |