HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → HCID 66757872, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 1-((tert-butoxy)carbonyl)-4-(((9H-fluoren-9-yl)methoxy)carbonyl)piperazine-2-carboxylic acid | HCID 2756797 | — |
| Solvent | Toluene methanol | HCID 21867641 | — |
| Product | HCID 66757872 | HCID 66757872 | — |
Reaction Steps
To a solution of piperazine-1,2,4-tricarboxylic acid 1-tert-butyl ester 4-(9H-fluoren-9-ylmethyl) ester (2.21 mmol) in toluene:methanol (9:1) was added equimolar trimethylsilyldiazomethane (2.0 M in hexanes) and the resulting mixture was stirred overnight at room temperature. The reaction mixture was concentrated in vacuo and purified using gradient elution from hexane/ethyl acetate (5%) to hexane/ethyl acetate (30%). ESI-MS m/z: 467 (M+1), UV retention time: 3.04 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058287B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-39fdb596811b4d29a39f9a7ccf8ff913 |
| Source note | uspto-grants-2011_11 |