Acetic acid, 2,2'-[methylenebis(sulfonyl)]bis- → 4-((1E)-2-(((E)-2-Fluoro-4-cyanostyrylsulfonyl)methylsulfonyl)vinyl)-3-fluorobenzonitrile

HRID 557096Notes

Reaction equation

HRID 557096 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([C:10]#[N:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.C([CH2:15][S:16]([CH2:19][S:20]([CH2:23][C:24](O)=O)(=[O:22])=[O:21])(=[O:18])=[O:17])(O)=O>C(O)(=O)C>[F:1][C:2]1[CH:9]=[C:8]([C:10]#[N:11])[CH:7]=[CH:6][C:3]=1/[CH:4]=[CH:15]/[S:16]([CH2:19][S:20](/[CH:23]=[CH:24]/[C:3]1[CH:6]=[CH:7][C:8]([C:10]#[N:11])=[CH:9][C:2]=1[F:1])(=[O:22])=[O:21])(=[O:18])=[O:17]

Participants

4

Reactant 2

HCID 2252641Acetic acid, 2,2'-[methylenebis(sulfonyl)]bis-HCID 27831503-Fluoro-4-formylbenzonitrile

Product 1

HCID 115972384-((1E)-2-(((E)-2-Fluoro-4-cyanostyrylsulfonyl)methylsulfonyl)vinyl)-3-fluorobenzonitrileYield 72%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2-fluoro-4-cyanobenzaldehyde (2 mmol) and carboxymethane-sulfonylmethanesulfonyl-acetic acid (1 mmol) in acetic acid (10 mL) was subjected to General Procedure 1, to yield the title compound in 72% yield. m.p. 268-270° C.

Sources & evidence

ORD record
ord-65654a6e964b42d595b6e724f3f8606e
Source dataset
uspto-grants-2011_11
Patent number
US08058313B2

Reaction notes

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