反应详情

温度

23.5 °C

To a round bottom flask containing mercaptoacetic acid (0.1 mol) dissolved in methanol (25 mL) is added 4-chloro-3-oxobutanoic acid (0.1 mol). The resulting mixture is heated at reflux temperature for about 2 hours. When the reaction is complete, the mixture is allowed to cool to room temperature (22-25° C.). Volatiles are removed under vacuum and the resulting residue is purified by column chromatography to yield 4-(carboxymethylthio)-3-oxobutanoic acid.

1. temperatureThe resulting mixture is heated
2. temperatureat reflux temperature for about 2 hours
3. customVolatiles are removed under vacuum
4. customthe resulting residue is purified by column chromatography